| Registro completo |
| Provedor de dados: |
Biocell
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| País: |
Argentina
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| Título: |
Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
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| Autores: |
Fontana,Vanina Andrea
Sanchez,Melisa
Cebral,Elisa
Calvo,Juan Carlos
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| Data: |
2010-04-01
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| Ano: |
2010
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| Palavras-chave: |
Cytokines
Embryo implantation
Placenta
Extracellular matrix
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| Resumo: |
Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-β on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1β activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000100005
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| Editor: |
Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
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| Formato: |
text/html
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| Fonte: |
Biocell v.34 n.1 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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